Ethyl 2-ethoxycarbonyl-2-hydroxy-4-(4-trifluoromethylphenyl)-4-oxobutanoate → 4-carboxy-6-(4-trifluoromethylphenyl)-2H-pyridazin-3-one

HRID 7946Notes

Reaction equation

HRID 7946 reaction equation
C([N:5]1C(=O)C(COS(C)(=O)=O)=CC(C2C=CC(C)=CC=2)=[N:6]1)C(C)C.C([O:27][C:28]([C:30](O)([CH2:36][C:37]([C:39]1[CH:44]=[CH:43][C:42]([C:45]([F:48])([F:47])[F:46])=[CH:41][CH:40]=1)=O)[C:31](OCC)=[O:32])=[O:29])C>>[C:28]([C:30]1[C:31](=[O:32])[NH:5][N:6]=[C:37]([C:39]2[CH:44]=[CH:43][C:42]([C:45]([F:48])([F:47])[F:46])=[CH:41][CH:40]=2)[CH:36]=1)([OH:27])=[O:29]

Participants

3

Reactant 2

HCID 21991505Ethyl 2-ethoxycarbonyl-2-hydroxy-4-(4-trifluoromethylphenyl)-4-oxobutanoateHCID 219915892-isobutyl-4-methanesulfonyloxymethyl-6-(4-methylphenyl)-2H-pyridazin-3-one

Product 1

HCID 219914274-carboxy-6-(4-trifluoromethylphenyl)-2H-pyridazin-3-oneYield 91.4%

Procedure

Following the procedure of Example 1 (4), ethyl 2-ethoxycarbonyl-2-hydroxy-4-(4-trifluoromethylphenyl)-4-oxobutanoate was reacted to yield the title compound as a pale brown crystalline powder (yield: 91.4%).

Workup

  1. customwas reacted

Sources & evidence

ORD record
ord-7e8c7a02041841ee99d759e10a103f84
Source dataset
uspto-grants-2006_08
Patent number
US07087606B2

Reaction notes

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