HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 2-ethoxycarbonyl-2-hydroxy-4-(4-trifluoromethylphenyl)-4-oxobutanoate → 4-carboxy-6-(4-trifluoromethylphenyl)-2H-pyridazin-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 2-ethoxycarbonyl-2-hydroxy-4-(4-trifluoromethylphenyl)-4-oxobutanoate | HCID 21991505 | — |
| Reactant | 2-isobutyl-4-methanesulfonyloxymethyl-6-(4-methylphenyl)-2H-pyridazin-3-one | HCID 21991589 | — |
| Product | 4-carboxy-6-(4-trifluoromethylphenyl)-2H-pyridazin-3-one | HCID 21991427 | 91.4% |
Reaction Steps
Following the procedure of Example 1 (4), ethyl 2-ethoxycarbonyl-2-hydroxy-4-(4-trifluoromethylphenyl)-4-oxobutanoate was reacted to yield the title compound as a pale brown crystalline powder (yield: 91.4%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07087606B2 |
| Source dataset | uspto-grants-2006_08 |
| ORD ID | ord-7e8c7a02041841ee99d759e10a103f84 |
| Source note | uspto-grants-2006_08 |