4-carboxy-6-(4-trifluoromethylphenyl)-2H-pyridazin-3-one → 4-methoxycarbonyl-6-(4-trifluoromethyl-phenyl)-2H-pyridazin-3-one

HRID 7947Notes

Reaction equation

HRID 7947 reaction equation
[CH2:1](N1CCN(CC2C(=O)N(CC(C)C)N=C(C3C=CC(C)=CC=3)C=2)CC1)C1C=CC=CC=1.[C:33]([C:36]1[C:37](=[O:52])[NH:38][N:39]=[C:40]([C:42]2[CH:47]=[CH:46][C:45]([C:48]([F:51])([F:50])[F:49])=[CH:44][CH:43]=2)[CH:41]=1)([OH:35])=[O:34]>>[CH3:1][O:34][C:33]([C:36]1[C:37](=[O:52])[NH:38][N:39]=[C:40]([C:42]2[CH:43]=[CH:44][C:45]([C:48]([F:51])([F:50])[F:49])=[CH:46][CH:47]=2)[CH:41]=1)=[O:35]

Participants

3

Reactant 2

HCID 219914274-carboxy-6-(4-trifluoromethylphenyl)-2H-pyridazin-3-oneHCID 219914874-(4-benzyl-1-piperazinyl)methyl-2-isobutyl-6-(4-methylphenyl)-2H-pyridazin-3-one

Product 1

HCID 219916074-methoxycarbonyl-6-(4-trifluoromethyl-phenyl)-2H-pyridazin-3-one

Procedure

Following the procedure of Example 1 (5), 4-carboxy-6-(4-trifluoromethylphenyl)-2H-pyridazin-3-one was reacted to yield the title compound as slightly yellow crystalline powder (yield: 88.5%).

Workup

  1. customwas reacted

Sources & evidence

ORD record
ord-b6623aafc3be420190abc80d4c625a60
Source dataset
uspto-grants-2006_08
Patent number
US07087606B2

Reaction notes

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