4-carboxy-2-isobutyl-6-(4-trifluoromethylphenyl)-2H-pyridazin-3-one → 4-hydroxymethyl-2-isobutyl-6-(4-trifluoromethylphenyl)-2H-pyridazin-3-one

HRID 7948Notes

Reaction equation

HRID 7948 reaction equation
FC1C=C(C2C(C)=C(O)C(=O)N(CC(C)C)N=2)C=CC=1C.[C:22]([C:25]1[C:26](=[O:45])[N:27]([CH2:41][CH:42]([CH3:44])[CH3:43])[N:28]=[C:29]([C:31]2[CH:36]=[CH:35][C:34]([C:37]([F:40])([F:39])[F:38])=[CH:33][CH:32]=2)[CH:30]=1)(O)=[O:23]>>[OH:23][CH2:22][C:25]1[C:26](=[O:45])[N:27]([CH2:41][CH:42]([CH3:43])[CH3:44])[N:28]=[C:29]([C:31]2[CH:32]=[CH:33][C:34]([C:37]([F:40])([F:38])[F:39])=[CH:35][CH:36]=2)[CH:30]=1

Participants

3

Reactant 2

HCID 219914554-carboxy-2-isobutyl-6-(4-trifluoromethylphenyl)-2H-pyridazin-3-oneHCID 178419042HCID 178419042, compound

Product 1

HCID 672136254-hydroxymethyl-2-isobutyl-6-(4-trifluoromethylphenyl)-2H-pyridazin-3-oneYield 28.1%

Procedure

Following the procedure of Example 1 (8), 4-carboxy-2-isobutyl-6-(4-trifluoromethylphenyl)-2H-pyridazin-3-one was reacted to yield the title compound as colorless fine-needles (yield: 28.1%).

Workup

  1. customwas reacted

Sources & evidence

ORD record
ord-38f54bda284b4a1c97d183b361a15695
Source dataset
uspto-grants-2006_08
Patent number
US07087606B2

Reaction notes

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