反应详情

To 1-((5-(benzyloxy)-6-methylpyridin-2-yl)methyl)-3-cyclopropyl-4-nitro-1H-indazole (5.1 g, 12.3 mmol) in EtOH (100 mL) was carefully added Pd/C (10%, 1.5 g, 1.41 mmol). The reaction mixture was evacuated with N2 and H2 (three times each), and stirred under a H2 balloon for 3 hours. The reaction mixture was then evacuated with N2, filtered through Celite® and washed with MeOH. The filtrate was concentrated to give the desired product (86%) which was used in the next step without further purification.

1. customThe reaction mixture was evacuated with N2 and H2 (three times each), and
2. customThe reaction mixture was then evacuated with N2
3. filtrationfiltered through Celite®
4. washwashed with MeOH
5. concentrationThe filtrate was concentrated