1-((5-(benzyloxy)-6-methylpyridin-2-yl)methyl)-3-cyclopropyl-4-nitro-1H-indazole → HCID 67251409, compound

Participants

Reaction Steps

To 1-((5-(benzyloxy)-6-methylpyridin-2-yl)methyl)-3-cyclopropyl-4-nitro-1H-indazole (5.1 g, 12.3 mmol) in EtOH (100 mL) was carefully added Pd/C (10%, 1.5 g, 1.41 mmol). The reaction mixture was evacuated with N2 and H2 (three times each), and stirred under a H2 balloon for 3 hours. The reaction mixture was then evacuated with N2, filtered through Celite® and washed with MeOH. The filtrate was concentrated to give the desired product (86%) which was used in the next step without further purification.

Provenance & Evidence