1-Methylpiperazine → 2-isobutyl-4-(4-methyl-1-piperazinyl)-methyl-6-(4-trifluoromethylphenyl)-2H-pyridazin-3-one

Participants

Role	Name	HCID	Charge
Reactant	1-Methylpiperazine	HCID 53167	—
Reactant	2-isobutyl-4-methanesulfonyloxymethyl-6-(4-trifluoromet hylphenyl)-2H-pyridazin-3-one	HCID 21991550	—
Reactant	4-(4-tert-butoxycarbonyl-1-piperazinyl)-methyl-6-(3-fluoro-4-methylphenyl)-2-isobutyl-2H-pyridazin-3-one	HCID 67214099	—
Product	2-isobutyl-4-(4-methyl-1-piperazinyl)-methyl-6-(4-trifluoromethylphenyl)-2H-pyridazin-3-one	HCID 21991484	81.1%

Reaction Steps

Following the procedure of Example 1 (10), 2-isobutyl-4-methanesulfonyloxymethyl-6-(4-trifluoromethylphenyl)-2H-pyridazin-3-one and 1-methylpiperazine were reacted to yield the title compound as a yellow oil (yield: 81.1%).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07087606B2
Source dataset	uspto-grants-2006_08
ORD ID	ord-335249b52a204b2e9d7f05e2d6baf82d
Source note	uspto-grants-2006_08