1-Methylpiperazine → 2-isobutyl-4-(4-methyl-1-piperazinyl)-methyl-6-(4-trifluoromethylphenyl)-2H-pyridazin-3-one

HRID 7951Notes

Reaction equation

HRID 7951 reaction equation
C(O[C:6]([N:8]1[CH2:13][CH2:12][N:11](C2C(=O)N(CC(C)C)N=C(C3C=CC(C)=C(F)C=3)C=2C)[CH2:10][CH2:9]1)=O)(C)(C)C.[CH2:34]([N:38]1[C:43](=[O:44])[C:42](COS(C)(=O)=O)=[CH:41][C:40]([C:51]2[CH:56]=[CH:55][C:54]([C:57]([F:60])([F:59])[F:58])=[CH:53][CH:52]=2)=[N:39]1)[CH:35]([CH3:37])[CH3:36].[CH3:61]N1CCNCC1>>[CH2:34]([N:38]1[C:43](=[O:44])[C:42]([N:11]2[CH2:12][CH2:13][N:8]([CH3:6])[CH2:9][CH2:10]2)=[C:41]([CH3:61])[C:40]([C:51]2[CH:52]=[CH:53][C:54]([C:57]([F:59])([F:60])[F:58])=[CH:55][CH:56]=2)=[N:39]1)[CH:35]([CH3:37])[CH3:36]

Participants

4

Reactant 3

HCID 531671-MethylpiperazineHCID 219915502-isobutyl-4-methanesulfonyloxymethyl-6-(4-trifluoromet hylphenyl)-2H-pyridazin-3-oneHCID 672140994-(4-tert-butoxycarbonyl-1-piperazinyl)-methyl-6-(3-fluoro-4-methylphenyl)-2-isobutyl-2H-pyridazin-3-one

Product 1

HCID 219914842-isobutyl-4-(4-methyl-1-piperazinyl)-methyl-6-(4-trifluoromethylphenyl)-2H-pyridazin-3-oneYield 81.1%

Procedure

Following the procedure of Example 1 (10), 2-isobutyl-4-methanesulfonyloxymethyl-6-(4-trifluoromethylphenyl)-2H-pyridazin-3-one and 1-methylpiperazine were reacted to yield the title compound as a yellow oil (yield: 81.1%).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-335249b52a204b2e9d7f05e2d6baf82d
Source dataset
uspto-grants-2006_08
Patent number
US07087606B2

Reaction notes

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