1-Methylpiperazine → 6-(4-biphenylyl)-2-isobutyl-4-(4-methyl-1-piperazinyl)methyl-2H-pyridazin-3-one

HRID 7954Notes

Reaction equation

HRID 7954 reaction equation
C(O[C:6]([N:8]1[CH2:13][CH2:12][N:11](C2C(=O)N(CC(C)C)N=C(C3C=CC(C)=C(F)C=3)C=2C)[CH2:10][CH2:9]1)=O)(C)(C)C.[C:34]1([C:57]2[CH:62]=[CH:61][CH:60]=[CH:59][CH:58]=2)[CH:39]=[CH:38][C:37]([C:40]2[CH:41]=[C:42]([CH2:51]OS(C)(=O)=O)[C:43](=[O:50])[N:44]([CH2:46][CH:47]([CH3:49])[CH3:48])[N:45]=2)=[CH:36][CH:35]=1.CN1CCNCC1>>[C:34]1([C:57]2[CH:58]=[CH:59][CH:60]=[CH:61][CH:62]=2)[CH:39]=[CH:38][C:37]([C:40]2[CH:41]=[C:42]([CH2:51][N:11]3[CH2:12][CH2:13][N:8]([CH3:6])[CH2:9][CH2:10]3)[C:43](=[O:50])[N:44]([CH2:46][CH:47]([CH3:49])[CH3:48])[N:45]=2)=[CH:36][CH:35]=1

Participants

4

Reactant 3

HCID 531671-MethylpiperazineHCID 219915756-(4-biphenylyl)-2-isobutyl-4-methane-sulfonyloxymethyl-2H-pyridazin-3-oneHCID 672140994-(4-tert-butoxycarbonyl-1-piperazinyl)-methyl-6-(3-fluoro-4-methylphenyl)-2-isobutyl-2H-pyridazin-3-one

Product 1

HCID 219916926-(4-biphenylyl)-2-isobutyl-4-(4-methyl-1-piperazinyl)methyl-2H-pyridazin-3-oneYield 68.2%

Procedure

Following the procedure of Example 1 (10), 6-(4-biphenylyl)-2-isobutyl-4-methanesulfonyloxymethyl-2H-pyridazin-3-one and 1-methylpiperazine were reacted to yield the title compound as a yellow oil (yield: 68.2%).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-c9f6ceb80a5a4bf7a99591e44b771470
Source dataset
uspto-grants-2006_08
Patent number
US07087606B2

Reaction notes

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