Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 79573Generated: October 29, 2026

HCID 68762213, compound → HCID 68761562, compound

https://huagongshe.com/reaction/79573

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHCID 68762213HCID 68762213—
CatalystHydrochloric AcidHCID 313—
CatalystPalladiumHCID 23938—
SolventMethanolHCID 887—
ProductHCID 68761562HCID 6876156293.8%

Reaction Steps

N-(4-(4-Benzylpiperazin-1-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)butyramide (0.070 g, 0.19 mmol) was dissolved in MeOH (1 mL). Pd/C (0.0197 g, 0.0185 mmol) was then added, followed by the addition of 3 drops of concentrated HCl. The reaction was then placed under a H2 balloon for 18 hours. The reaction was then filtered, washed with MeOH, and concentrated to give the crude product N-(4-(piperazin-1-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)butyramide (0.050 g, 93.8% yield).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08841304B2
Source datasetuspto-grants-2014_09
ORD IDord-521b0c305ac943fc9b03524b907a1f7b
Source noteuspto-grants-2014_09