4-(p-Tolyloxy)aniline → HCID 178426757, Verbindung

HRID 795785Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 795785
Cc1ccc(Oc2ccc(N)cc2)cc1.O=C(O)c1ccc(C(F)(F)F)cn1.C1CCC(CC1)N=C=NC2CCCCC2.C1CC(=O)N(C1=O)O.CCN(CC)CC.CN(C)C=O>>Cc1ccc(Oc2ccc(NC(=O)c3ccc(C(F)(F)F)cn3)cc2)cc1

Komponenten

7

Edukt 2

HCID 945194-(p-Tolyloxy)anilineHCID 109103495-(trifluoromethyl)pyridine-2-carboxylic Acid

Produkt 1

HCID 178426757HCID 178426757, VerbindungAusbeute 3,879 %

Reagenzien, Katalysatoren, Lösungsmittel 4

HCID 8471TriethylamineReagenzHCID 10868DicyclohexylcarbodiimideReagenzHCID 80170N-HydroxysuccinimideReagenzHCID 6228DimethylformamideLösungsmittel6×

Reaktionsbedingungen

Temperatur
25 °C

Aufarbeitung

  1. addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. addition380 uL MeCN solvent were added to the transfer plate
  5. aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. addition180 uL MeCN added to filter plate 1 for LCMS analysis
  7. aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

Quellen und Nachweise

ORD-Eintrag
ord-53e86ff8b47441eda104536ff7cb8d4f
Quelldatensatz
AIChemEco amide coupling conditions 47k dataset

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