Ethyl 4-(3,4-difluorophenyl)-2-ethoxycarbonyl-2-hydroxy-4-oxo-butanoate → 4-carboxy-6-(3,4-difluorophenyl)-2H-pyridazin-3-one

HRID 7960Notes

Reaction equation

HRID 7960 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([C:19]([O:21]C)=[O:20])[C:11](=[O:18])[N:12](CC(C)C)[N:13]=2)=[CH:4][C:3]=1C.[F:24]C1C=C(C(=O)CC(C(OCC)=O)(O)C(OCC)=O)C=CC=1F>>[C:19]([C:10]1[C:11](=[O:18])[NH:12][N:13]=[C:8]([C:5]2[CH:6]=[CH:7][C:2]([F:1])=[C:3]([F:24])[CH:4]=2)[CH:9]=1)([OH:21])=[O:20]

Participants

3

Reactant 2

HCID 21991446Ethyl 4-(3,4-difluorophenyl)-2-ethoxycarbonyl-2-hydroxy-4-oxo-butanoateHCID 219915336-(4-fluoro-3-methylphenyl)-2-isobutyl-4-methoxycarbonyl-2H-pyridazin-3-one

Product 1

HCID 219916754-carboxy-6-(3,4-difluorophenyl)-2H-pyridazin-3-oneYield 88.9%

Procedure

Following the procedure of Example 1 (4), ethyl 4-(3,4-difluorophenyl)-2-ethoxycarbonyl-2-hydroxy-4-oxo-butanoate was reacted to yield the title compound as a pale yellow crystalline powder (yield: 88.9%).

Workup

  1. customwas reacted

Sources & evidence

ORD record
ord-c8bc44c09c944120ae7f421e56636c18
Source dataset
uspto-grants-2006_08
Patent number
US07087606B2

Reaction notes

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