HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 4-(3,4-difluorophenyl)-2-ethoxycarbonyl-2-hydroxy-4-oxo-butanoate → 4-carboxy-6-(3,4-difluorophenyl)-2H-pyridazin-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 4-(3,4-difluorophenyl)-2-ethoxycarbonyl-2-hydroxy-4-oxo-butanoate | HCID 21991446 | — |
| Reactant | 6-(4-fluoro-3-methylphenyl)-2-isobutyl-4-methoxycarbonyl-2H-pyridazin-3-one | HCID 21991533 | — |
| Product | 4-carboxy-6-(3,4-difluorophenyl)-2H-pyridazin-3-one | HCID 21991675 | 88.9% |
Reaction Steps
Following the procedure of Example 1 (4), ethyl 4-(3,4-difluorophenyl)-2-ethoxycarbonyl-2-hydroxy-4-oxo-butanoate was reacted to yield the title compound as a pale yellow crystalline powder (yield: 88.9%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07087606B2 |
| Source dataset | uspto-grants-2006_08 |
| ORD ID | ord-c8bc44c09c944120ae7f421e56636c18 |
| Source note | uspto-grants-2006_08 |