反应详情

N-(4-(4-Benzylpiperazin-1-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)acetamide (0.150 g, 0.429 mmol) was placed in MeOH (3 mL). Pd/C (0.0914 g, 0.0429 mmol) was then added, followed by the addition of 3 drops of concentrated HCl. The reaction was then placed under a H2 balloon for 3 hours. The reaction was then filtered, but the product was insoluble. The solids were slurried with 1:1 MeOH:THF (5×) and filtered. The filtrate was then concentrated to give the crude product N-(4-(piperazin-1-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)acetamide (0.110 g, 77.1% yield), which was used without further purification.

1. customfor 3 hours
2. filtrationThe reaction was then filtered
3. filtrationTHF (5×) and filtered
4. concentrationThe filtrate was then concentrated