6-(4-Fluoro-3-methylphenyl)-2-isobutyl-4-methane-sulfonyloxymethyl-2H-pyridazin-3-one → 4-carboxy-6-(3,4-difluorophenyl)-2-isobutyl-2H-pyridazin-3-one

HRID 7962Notes

Reaction equation

HRID 7962 reaction equation
FC1C=CC(C2C=C(COS(C)(=O)=O)C(=O)N(CC(C)C)N=2)=CC=1C.[F:26][C:27]1[CH:28]=[C:29]([C:34]2[CH:35]=[C:36]([C:45]([O:47]C)=[O:46])[C:37](=[O:44])[N:38]([CH2:40][CH:41]([CH3:43])[CH3:42])[N:39]=2)[CH:30]=[CH:31][C:32]=1[F:33]>>[C:45]([C:36]1[C:37](=[O:44])[N:38]([CH2:40][CH:41]([CH3:42])[CH3:43])[N:39]=[C:34]([C:29]2[CH:30]=[CH:31][C:32]([F:33])=[C:27]([F:26])[CH:28]=2)[CH:35]=1)([OH:47])=[O:46]

Participants

3

Reactant 2

HCID 219914576-(4-Fluoro-3-methylphenyl)-2-isobutyl-4-methane-sulfonyloxymethyl-2H-pyridazin-3-oneHCID 219916596-(3,4-difluorophenyl)-2-isobutyl-4-methoxycarbonyl-2H-pyridazin-3-one

Product 1

HCID 219916384-carboxy-6-(3,4-difluorophenyl)-2-isobutyl-2H-pyridazin-3-oneYield 91.4%

Procedure

Following the procedure of Example 1 (7), 6-(3,4-difluorophenyl)-2-isobutyl-4-methoxycarbonyl-2H-pyridazin-3-one was reacted to yield the title compound as colorless fine needles (yield: 91.4%).

Workup

  1. customwas reacted

Sources & evidence

ORD record
ord-714bb13112614b41842047c2a94caf55
Source dataset
uspto-grants-2006_08
Patent number
US07087606B2

Reaction notes

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