1-Methylpiperazine → 6-(3,4-difluorophenyl)-2-isobutyl-4-(4-methyl-1-piperazinyl)methyl-2H-pyridazin-3-one

HRID 7966Notes

Reaction equation

HRID 7966 reaction equation
C(O[C:6]([N:8]1[CH2:13][CH2:12][N:11](C2C(=O)N(CC(C)C)N=C(C3C=CC(C)=C(F)C=3)C=2C)[CH2:10][CH2:9]1)=O)(C)(C)C.[F:34][C:35]1[CH:36]=[C:37]([C:42]2[CH:43]=[C:44]([CH2:53]OS(C)(=O)=O)[C:45](=[O:52])[N:46]([CH2:48][CH:49]([CH3:51])[CH3:50])[N:47]=2)[CH:38]=[CH:39][C:40]=1[F:41].CN1CCNCC1>>[F:34][C:35]1[CH:36]=[C:37]([C:42]2[CH:43]=[C:44]([CH2:53][N:11]3[CH2:12][CH2:13][N:8]([CH3:6])[CH2:9][CH2:10]3)[C:45](=[O:52])[N:46]([CH2:48][CH:49]([CH3:51])[CH3:50])[N:47]=2)[CH:38]=[CH:39][C:40]=1[F:41]

Participants

4

Reactant 3

HCID 531671-MethylpiperazineHCID 219915206-(3,4-difluorophenyl)-2-isobutyl-4-methanesulfonyloxym ethyl-2H-pyridazin-3-oneHCID 672140994-(4-tert-butoxycarbonyl-1-piperazinyl)-methyl-6-(3-fluoro-4-methylphenyl)-2-isobutyl-2H-pyridazin-3-one

Product 1

HCID 219916616-(3,4-difluorophenyl)-2-isobutyl-4-(4-methyl-1-piperazinyl)methyl-2H-pyridazin-3-oneYield 79.1%

Procedure

Following the procedure of Example 1 (10), 6-(3,4-difluorophenyl)-2-isobutyl-4-methanesulfonyloxymethyl-2H-pyridazin-3-one and 1-methylpiperazine were reacted to yield the title compound as a yellow oil (yield: 79.1%).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-f79b7d8fd2e84a7ab7b6864720a4cbf1
Source dataset
uspto-grants-2006_08
Patent number
US07087606B2

Reaction notes

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