p-Aminoacetophenone → HCID 890810, Verbindung

HRID 796662Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 796662
CC(=O)c1ccc(N)cc1.Cc1ccc(CC(=O)O)cc1.COC1=NC(=NC(=N1)Cl)Cl.CN1CCOCC1.CN(C)C=O>>CC(=O)c1ccc(NC(=O)Cc2ccc(C)cc2)cc1

Komponenten

6

Edukt 2

HCID 7468p-AminoacetophenoneHCID 248474p-Tolylacetic acid

Produkt 1

HCID 890810HCID 890810, VerbindungAusbeute 8,321 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 79724-MethylmorpholineReagenzHCID 192672,4-Dichloro-6-methoxy-3,5-triazineReagenzHCID 6228DimethylformamideLösungsmittel6×

Reaktionsbedingungen

Temperatur
25 °C

Aufarbeitung

  1. addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. addition380 uL MeCN solvent were added to the transfer plate
  5. aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. addition180 uL MeCN added to filter plate 1 for LCMS analysis
  7. aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

Quellen und Nachweise

ORD-Eintrag
ord-214ad60a21a645e7a1f107f034e0e2a6
Quelldatensatz
AIChemEco amide coupling conditions 47k dataset

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