4-carboxy-6-(2,4-difluorophenyl)-2-isobutyl-2H-pyridazin-3-one → 6-(2,4-difluorophenyl)-4-hydroxymethyl-2-isobutyl-2H-pyridazin-3-one

HRID 7971Notes

Reaction equation

HRID 7971 reaction equation
C(OC(N1CCN(C2C(=O)N(CC(C)C)N=C(C3C=CC(F)=C(F)C=3)C=2C)CC1)=O)(C)(C)C.[C:34]([C:37]1[C:38](=[O:55])[N:39]([CH2:51][CH:52]([CH3:54])[CH3:53])[N:40]=[C:41]([C:43]2[CH:48]=[CH:47][C:46]([F:49])=[CH:45][C:44]=2[F:50])[CH:42]=1)(O)=[O:35]>>[F:50][C:44]1[CH:45]=[C:46]([F:49])[CH:47]=[CH:48][C:43]=1[C:41]1[CH:42]=[C:37]([CH2:34][OH:35])[C:38](=[O:55])[N:39]([CH2:51][CH:52]([CH3:53])[CH3:54])[N:40]=1

Participants

3

Reactant 2

HCID 219916134-carboxy-6-(2,4-difluorophenyl)-2-isobutyl-2H-pyridazin-3-oneHCID 672132104-(4-tert-butoxycarbonyl-1-piperazinyl)-methyl-6-(3,4-difluorophenyl)-2-isobutyl-2H-pyridazin-3-one

Product 1

HCID 219916626-(2,4-difluorophenyl)-4-hydroxymethyl-2-isobutyl-2H-pyridazin-3-oneYield 45%

Procedure

Following the procedure of Example 1 (8), 4-carboxy-6-(2,4-difluorophenyl)-2-isobutyl-2H-pyridazin-3-one was reacted to yield the title compound as a pale yellow oil (yield: 45.0%).

Workup

  1. customwas reacted

Sources & evidence

ORD record
ord-394277e0d63a4f63977661e2548de12b
Source dataset
uspto-grants-2006_08
Patent number
US07087606B2

Reaction notes

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