HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-carboxy-6-(2,4-difluorophenyl)-2-isobutyl-2H-pyridazin-3-one → 6-(2,4-difluorophenyl)-4-hydroxymethyl-2-isobutyl-2H-pyridazin-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-carboxy-6-(2,4-difluorophenyl)-2-isobutyl-2H-pyridazin-3-one | HCID 21991613 | — |
| Reactant | 4-(4-tert-butoxycarbonyl-1-piperazinyl)-methyl-6-(3,4-difluorophenyl)-2-isobutyl-2H-pyridazin-3-one | HCID 67213210 | — |
| Product | 6-(2,4-difluorophenyl)-4-hydroxymethyl-2-isobutyl-2H-pyridazin-3-one | HCID 21991662 | 45% |
Reaction Steps
Following the procedure of Example 1 (8), 4-carboxy-6-(2,4-difluorophenyl)-2-isobutyl-2H-pyridazin-3-one was reacted to yield the title compound as a pale yellow oil (yield: 45.0%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07087606B2 |
| Source dataset | uspto-grants-2006_08 |
| ORD ID | ord-394277e0d63a4f63977661e2548de12b |
| Source note | uspto-grants-2006_08 |