Diethylamine → 4-diethylaminomethyl-6-(2,4-difluorophenyl)-2-isobutyl-2H-pyridazin-3-one

HRID 7973Notes

Reaction equation

HRID 7973 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:10]=[C:11]([C:20](OC)=O)[C:12](=[O:19])[N:13]([CH2:15][CH:16]([CH3:18])[CH3:17])[N:14]=1.FC1C=C(F)C=CC=1C1C=[C:34](COS(C)(=O)=O)[C:35](=O)[N:36]([CH2:38][CH:39](C)C)N=1.C(NCC)C>>[CH2:35]([N:36]([CH2:20][C:11]1[C:12](=[O:19])[N:13]([CH2:15][CH:16]([CH3:18])[CH3:17])[N:14]=[C:9]([C:3]2[CH:4]=[CH:5][C:6]([F:8])=[CH:7][C:2]=2[F:1])[CH:10]=1)[CH2:38][CH3:39])[CH3:34]

Participants

4

Reactant 3

HCID 8021DiethylamineHCID 219914116-(2,4-difluorophenyl)-2-isobutyl-4-methoxycarbonyl-2H-pyridazin-3-oneHCID 219914166-(2,4-difluorophenyl)-2-isobutyl-4-methanesulfonyloxym ethyl-2H-pyridazin-3-one

Product 1

HCID 219916054-diethylaminomethyl-6-(2,4-difluorophenyl)-2-isobutyl-2H-pyridazin-3-one

Procedure

Following the procedure of Example 9 (4), 6-(2,4-difluorophenyl)-2-isobutyl-4-methanesulfonyloxymethyl-2H-pyridazin-3-one and diethylamine were reacted to yield the title compound as a pale yellow oil (yield: quantitative).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-7f859e611fc340788dd94777d9e88e65
Source dataset
uspto-grants-2006_08
Patent number
US07087606B2

Reaction notes

Loading…