Benzyl Chloride → 2-benzyl-6-(4-fluoro-3-methylphenyl)-4-methoxycarbonyl-2H-pyridazin-3-one

HRID 7976Notes

Reaction equation

HRID 7976 reaction equation
F[C:2]1[CH:7]=[C:6](F)[CH:5]=[CH:4][C:3]=1[C:9]1C=C(CO)C(=O)N(CC(C)C)N=1.[F:22][C:23]1[CH:28]=[CH:27][C:26]([C:29]2[CH:30]=[C:31]([C:36]([O:38][CH3:39])=[O:37])[C:32](=[O:35])[NH:33][N:34]=2)=[CH:25][C:24]=1[CH3:40].C(Cl)C1C=CC=CC=1>>[CH2:9]([N:33]1[C:32](=[O:35])[C:31]([C:36]([O:38][CH3:39])=[O:37])=[CH:30][C:29]([C:26]2[CH:27]=[CH:28][C:23]([F:22])=[C:24]([CH3:40])[CH:25]=2)=[N:34]1)[C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:2]=1

Participants

4

Reactant 3

HCID 7503Benzyl ChlorideHCID 219914596-(4-fluoro-3-methylphenyl)-4-methoxycarbonyl-2H-pyridazin-3-oneHCID 219916626-(2,4-difluorophenyl)-4-hydroxymethyl-2-isobutyl-2H-pyridazin-3-one

Product 1

HCID 219917142-benzyl-6-(4-fluoro-3-methylphenyl)-4-methoxycarbonyl-2H-pyridazin-3-oneYield 71%

Procedure

Following the procedure of Example 1 (6), 6-(4-fluoro-3-methylphenyl)-4-methoxycarbonyl-2H-pyridazin-3-one and benzyl chloride were reacted to yield the title compound as yellow needles (yield: 71.0%).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-c691731ee11f4e87b3c2983c4e59d2bb
Source dataset
uspto-grants-2006_08
Patent number
US07087606B2

Reaction notes

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