6-(2,4-difluorophenyl)-2-isobutyl-4-methanesulfonyloxym ethyl-2H-pyridazin-3-one → 2-benzyl-4-carboxy-6-(4-fluoro-3-methylphenyl)-2H-pyridazin-3-one

HRID 7977Notes

Reaction equation

HRID 7977 reaction equation
FC1C=C(F)C=CC=1C1C=C(COS(C)(=O)=O)C(=O)N(CC(C)C)N=1.[CH2:26]([N:33]1[C:38](=[O:39])[C:37]([C:40]([O:42]C)=[O:41])=[CH:36][C:35]([C:44]2[CH:49]=[CH:48][C:47]([F:50])=[C:46]([CH3:51])[CH:45]=2)=[N:34]1)[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1>>[CH2:26]([N:33]1[C:38](=[O:39])[C:37]([C:40]([OH:42])=[O:41])=[CH:36][C:35]([C:44]2[CH:49]=[CH:48][C:47]([F:50])=[C:46]([CH3:51])[CH:45]=2)=[N:34]1)[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1

Participants

3

Reactant 2

HCID 219914166-(2,4-difluorophenyl)-2-isobutyl-4-methanesulfonyloxym ethyl-2H-pyridazin-3-oneHCID 219917142-benzyl-6-(4-fluoro-3-methylphenyl)-4-methoxycarbonyl-2H-pyridazin-3-one

Product 1

HCID 219915652-benzyl-4-carboxy-6-(4-fluoro-3-methylphenyl)-2H-pyridazin-3-oneYield 65.2%

Procedure

Following the procedure of Example 1 (7), 2-benzyl-6-(4-fluoro-3-methylphenyl)-4-methoxycarbonyl-2H-pyridazin-3-one was reacted to yield the title compound as a pale yellow crystalline powder (yield: 65.2%).

Workup

  1. customwas reacted

Sources & evidence

ORD record
ord-e4cb384438354d1495d3e3a819bb7dae
Source dataset
uspto-grants-2006_08
Patent number
US07087606B2

Reaction notes

Loading…