6-(2,4-difluorophenyl)-2-isobutyl-4-methanesulfonyloxym ethyl-2H-pyridazin-3-one → 4-carboxy-2-cinnamyl-6-(4-fluoro-3-methylphenyl)-2H-pyridazin-3-one

HRID 7982Notes

Reaction equation

HRID 7982 reaction equation
FC1C=C(F)C=CC=1C1C=C(COS(C)(=O)=O)C(=O)N(CC(C)C)N=1.[CH2:26]([N:35]1[C:40](=[O:41])[C:39]([C:42]([O:44]C)=[O:43])=[CH:38][C:37]([C:46]2[CH:51]=[CH:50][C:49]([F:52])=[C:48]([CH3:53])[CH:47]=2)=[N:36]1)[CH:27]=[CH:28][C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1>>[C:42]([C:39]1[C:40](=[O:41])[N:35]([CH2:26][CH:27]=[CH:28][C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[N:36]=[C:37]([C:46]2[CH:51]=[CH:50][C:49]([F:52])=[C:48]([CH3:53])[CH:47]=2)[CH:38]=1)([OH:44])=[O:43]

Participants

3

Reactant 2

HCID 219914166-(2,4-difluorophenyl)-2-isobutyl-4-methanesulfonyloxym ethyl-2H-pyridazin-3-oneHCID 672134522-cinnamyl-6-(4-fluoro-3-methylphenyl)-4-methoxycarbonyl-2H-pyridazin-3-one

Product 1

HCID 672133534-carboxy-2-cinnamyl-6-(4-fluoro-3-methylphenyl)-2H-pyridazin-3-oneYield 85.1%

Procedure

Following the procedure of Example 1 (7), 2-cinnamyl-6-(4-fluoro-3-methylphenyl)-4-methoxycarbonyl-2H-pyridazin-3-one was reacted to yield the title compound as pale yellow needles (yield: 85.1%).

Workup

  1. customwas reacted

Sources & evidence

ORD record
ord-fcf274a54078452a9ad50b4702e61f52
Source dataset
uspto-grants-2006_08
Patent number
US07087606B2

Reaction notes

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