1-Methylpiperazine → 2-cinnamyl-6-(4-fluoro-3-methylphenyl)-4-(4-methyl-1-piperazinyl)methyl-2H-pyridazin-3-one

HRID 7985Notes

Reaction equation

HRID 7985 reaction equation
C(O[C:6]([N:8]1[CH2:13][CH2:12][N:11](C2C(=O)N(CC(C)C)N=C(C3C=CC(C)=C(F)C=3)C=2C)[CH2:10][CH2:9]1)=O)(C)(C)C.[CH2:34]([N:43]1[C:48](=[O:49])[C:47]([CH2:50]OS(C)(=O)=O)=[CH:46][C:45]([C:56]2[CH:61]=[CH:60][C:59]([F:62])=[C:58]([CH3:63])[CH:57]=2)=[N:44]1)[CH:35]=[CH:36][C:37]1[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=1.CN1CCNCC1>>[CH2:34]([N:43]1[C:48](=[O:49])[C:47]([CH2:50][N:11]2[CH2:12][CH2:13][N:8]([CH3:6])[CH2:9][CH2:10]2)=[CH:46][C:45]([C:56]2[CH:61]=[CH:60][C:59]([F:62])=[C:58]([CH3:63])[CH:57]=2)=[N:44]1)[CH:35]=[CH:36][C:37]1[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=1

Participants

4

Reactant 3

HCID 531671-MethylpiperazineHCID 672140994-(4-tert-butoxycarbonyl-1-piperazinyl)-methyl-6-(3-fluoro-4-methylphenyl)-2-isobutyl-2H-pyridazin-3-oneHCID 738582982-cinnamyl-6-(4-fluoro-3-methylphenyl)-4-methanesulfonyloxy methyl-2H-pyridazin-3-one

Product 1

HCID 672132412-cinnamyl-6-(4-fluoro-3-methylphenyl)-4-(4-methyl-1-piperazinyl)methyl-2H-pyridazin-3-oneYield 80.1%

Procedure

Following the procedure of Example 1 (10), 2-cinnamyl-6-(4-fluoro-3-methylphenyl)-4-methanesulfonyloxymethyl-2H-pyridazin-3-one and 1-methylpiperazine were reacted to yield the title compound as a yellow oil (yield: 80.1%).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-5efab2f861dd4da19edc62163b941916
Source dataset
uspto-grants-2006_08
Patent number
US07087606B2

Reaction notes

Loading…