反应详情

温度

25 °C

The mixture of 1,4-dibromo-2-nitro-benzene (25 g, 89 mmol) and copper powder (12.5 g, 197 mmol) in DMF (150 ml) was heated at 137 C for 2 hours. The mixture was cooled to 25° C. and was quenched with water. The mixture was extracted with EtOAc (2×). The combined organic solution was washed with water and brine and was dried with Na2SO4. Concentration and purification by flash column chromatography (hexanes/EtOAc) gave 4,4′-dibromo-2,2′-dinitro-biphenyl (13.6 g).

1. temperaturewas heated at 137 C for 2 hours
2. customwas quenched with water
3. extractionThe mixture was extracted with EtOAc (2×)
4. washThe combined organic solution was washed with water and brine
5. dry with materialwas dried with Na2SO4
6. concentrationConcentration and purification by flash column chromatography (hexanes/EtOAc)