2-Cyclopropylmethyl-4-methoxycarbonyl-6-[4-(methylthio)phenyl]-2H-pyridazin-3-one → 4-carboxy-2-cyclopropylmethyl-6-[4-(methylthio)phenyl]-2H-pyridazin-3-one

HRID 7990Notes

Reaction equation

HRID 7990 reaction equation
FC1C=C(F)C=CC=1C1C=C(COS(C)(=O)=O)C(=O)N(CC(C)C)N=1.[CH:26]1([CH2:29][N:30]2[C:35](=[O:36])[C:34]([C:37]([O:39]C)=[O:38])=[CH:33][C:32]([C:41]3[CH:46]=[CH:45][C:44]([S:47][CH3:48])=[CH:43][CH:42]=3)=[N:31]2)[CH2:28][CH2:27]1>>[C:37]([C:34]1[C:35](=[O:36])[N:30]([CH2:29][CH:26]2[CH2:28][CH2:27]2)[N:31]=[C:32]([C:41]2[CH:46]=[CH:45][C:44]([S:47][CH3:48])=[CH:43][CH:42]=2)[CH:33]=1)([OH:39])=[O:38]

Participants

3

Reactant 2

HCID 129717712-Cyclopropylmethyl-4-methoxycarbonyl-6-[4-(methylthio)phenyl]-2H-pyridazin-3-oneHCID 219914166-(2,4-difluorophenyl)-2-isobutyl-4-methanesulfonyloxym ethyl-2H-pyridazin-3-one

Product 1

HCID 219914244-carboxy-2-cyclopropylmethyl-6-[4-(methylthio)phenyl]-2H-pyridazin-3-oneYield 98.2%

Procedure

Following the procedure of Example 1 (7), 2-cyclopropylmethyl-4-methoxycarbonyl-6-[4-(methylthio)-phenyl]-2H-pyridazin-3-one was reacted to yield the title compound as a yellow crystalline powder (yield: 98.2%).

Workup

  1. customwas reacted

Sources & evidence

ORD record
ord-abb0a210dd504a5dadf137cc2aaedd23
Source dataset
uspto-grants-2006_08
Patent number
US07087606B2

Reaction notes

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