Phenyltrimethylammonium bromide dibromide → HCID 58545558, compound

HRID 79936Notes

Reaction equation

HRID 79936 reaction equation
[S:1]1[C:5]([C:6](=[O:8])[CH3:7])=[CH:4][CH:3]2[S:9][CH:10]=[CH:11][CH:2]12.[Br-:12].[Br-].[Br-].C1([N+](C)(C)C)C=CC=CC=1.C1([N+](C)(C)C)C=CC=CC=1.C1([N+](C)(C)C)C=CC=CC=1>C1COCC1>[Br:12][CH2:7][C:6]([C:5]1[S:1][CH:2]2[CH:11]=[CH:10][S:9][CH:3]2[CH:4]=1)=[O:8]

Participants

4

Reactant 2

HCID 17977687Phenyltrimethylammonium bromide dibromideHCID 58545574HCID 58545574, compound

Product 1

HCID 58545558HCID 58545558, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

1-(3a,6a-Dihydro-thieno[3,2-b]thiophen-2-yl)-ethanone (453 mg, 2.48 mmol) was dissolved in THF (12 mL) and phenyltrimethylammonium tribromide (932 mg, 2.48 mmol) was added. After stirring for 1 h, the suspension was filtered over CELITE. The filtrate was diluted with diethyl ether, then washed with saturated aqueous NaHCO3 and brine then dried over MgSO4, filtered and concentrated to afford the title compound which was carried on without purification.

Workup

  1. filtrationthe suspension was filtered over CELITE
  2. additionThe filtrate was diluted with diethyl ether
  3. washwashed with saturated aqueous NaHCO3 and brine
  4. dry with materialthen dried over MgSO4
  5. filtrationfiltered
  6. concentrationconcentrated

Sources & evidence

ORD record
ord-7e09ee270ba2465f88cc80618bdc441c
Source dataset
uspto-grants-2014_09
Patent number
US08841278B2

Reaction notes

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