Acetate → Ethyl 2-fluoro-4-[6-(1-trityl-1H-pyrazol-4-yl)-quinazolin-4-yl]benzoate
Reaction equation
[C:24]([c:25]1[cH:26][cH:27][cH:28][cH:29][cH:30]1)([c:31]1[cH:32][cH:33][cH:34][cH:35][cH:36]1)([c:37]1[cH:38][cH:39][cH:40][cH:41][cH:42]1)[n:43]1[n:44][cH:45][c:46]([B:48]([OH:49])[OH:50])[cH:47]1.[C:53]([P:54]([C:55]([CH3:56])([CH3:57])[CH3:58])[c:59]1[cH:60][cH:61][cH:62][cH:63][c:64]1-[c:65]1[cH:66][cH:67][cH:68][cH:69][cH:70]1)([CH3:71])([CH3:72])[CH3:73].[CH3:84][N:85]([CH3:86])[CH:87]=[O:88].[Cl:1][c:2]1[cH:3][c:4]2[c:5](-[c:12]3[cH:13][c:14]([F:23])[c:15]([C:16](=[O:17])[O:18][CH2:19][CH3:20])[cH:21][cH:22]3)[n:6][cH:7][n:8][c:9]2[cH:10][cH:11]1.[F-:51].[K+:52].[O-:75][C:76]([CH3:77])=[O:78].[O-:79][C:80]([CH3:81])=[O:82].[OH2:83].[Pd+2:74]>>[c:2]1(-[c:46]2[cH:45][n:44][n:43]([C:24]([c:25]3[cH:26][cH:27][cH:28][cH:29][cH:30]3)([c:31]3[cH:32][cH:33][cH:34][cH:35][cH:36]3)[c:37]3[cH:38][cH:39][cH:40][cH:41][cH:42]3)[cH:47]2)[cH:3][c:4]2[c:5](-[c:12]3[cH:13][c:14]([F:23])[c:15]([C:16](=[O:17])[O:18][CH2:19][CH3:20])[cH:21][cH:22]3)[n:6][cH:7][n:8][c:9]2[cH:10][cH:11]1Participants
10
Reactant 9
HCID 175Acetate2×
HCID 813Potassium Cation
HCID 962Water
HCID 6228Dimethylformamide
HCID 28179Fluoride Ion
HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)
HCID 27342152-(Di-tert-butylphosphino)biphenyl
HCID 22031224Ethyl 4-(6-chloroquinazolin-4-yl)-2-fluorobenzoate
HCID 22031737(1-Trityl-1H-pyrazol-4-yl)boronic acidProduct 1
Sources & evidence
- ORD record
- ord-71ceec7283ae4b8dac7e3de3bdc4ea54
- Source dataset
- Test data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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