1-Methylpiperazine → 2-cyclopropylmethyl-4-(4-methyl-1-piperazinyl)methyl-6-[4-(methylsulfinyl)phenyl]-2H-pyridazin-3-one

HRID 7997Notes

Reaction equation

HRID 7997 reaction equation
C(O[C:6]([N:8]1[CH2:13][CH2:12][N:11](C2C(=O)N(CC(C)C)N=C(C3C=CC(C)=C(F)C=3)C=2C)[CH2:10][CH2:9]1)=O)(C)(C)C.[CH:34]1([N:37]2[C:42](=[O:43])[C:41]([CH2:44]OS(C)(=O)=O)=[CH:40][C:39]([C:50]3[CH:55]=[CH:54][C:53]([S:56]([CH3:58])=[O:57])=[CH:52][CH:51]=3)=[N:38]2)[CH2:36][CH2:35]1.[CH3:59]N1CCNCC1>>[CH:35]1([CH2:34][N:37]2[C:42](=[O:43])[C:41]([CH2:44][N:11]3[CH2:12][CH2:13][N:8]([CH3:6])[CH2:9][CH2:10]3)=[CH:40][C:39]([C:50]3[CH:55]=[CH:54][C:53]([S:56]([CH3:58])=[O:57])=[CH:52][CH:51]=3)=[N:38]2)[CH2:59][CH2:36]1

Participants

4

Reactant 3

HCID 531671-MethylpiperazineHCID 219915742-cyclopropyl-4-methanesulfonyloxymethyl-6-[4-(methyl-sulfi nyl)phenyl]-2H-pyridazin-3-oneHCID 672140994-(4-tert-butoxycarbonyl-1-piperazinyl)-methyl-6-(3-fluoro-4-methylphenyl)-2-isobutyl-2H-pyridazin-3-one

Product 1

HCID 219914042-cyclopropylmethyl-4-(4-methyl-1-piperazinyl)methyl-6-[4-(methylsulfinyl)phenyl]-2H-pyridazin-3-oneYield 60.6%

Procedure

Following the procedure of Example 1 (10), 2-cyclopropyl-4-methanesulfonyloxymethyl-6-[4-(methyl-sulfinyl)phenyl]-2H-pyridazin-3-one and 1-methylpiperazine were reacted to yield the title compound as a yellow oil (yield: 60.6%).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-80ed7fce2c314442ab3c85670fbca824
Source dataset
uspto-grants-2006_08
Patent number
US07087606B2

Reaction notes

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