Chloride → 2-Amino-5-(4'-fluorobenzyl)benzonitrile

HRID 799807Notes

Reaction equation

HRID 799807 reaction equation
[Cl-:11].[F:12][c:13]1[cH:14][cH:15][c:16]([CH2:17][Zn+:18])[cH:19][cH:20]1.[NH2:1][c:2]1[c:3]([C:4]#[N:5])[cH:6][c:7]([I:10])[cH:8][cH:9]1.[NH2:21][c:22]1[cH:23][cH:24][c:25]([CH2:26][c:27]2[cH:28][cH:29][cH:30][cH:31][cH:32]2)[cH:33][c:34]1[C:35]#[N:36]>>[NH2:1][c:2]1[c:3]([C:4]#[N:5])[cH:6][c:7]([CH2:17][c:16]2[cH:15][cH:14][c:13]([F:12])[cH:20][cH:19]2)[cH:8][cH:9]1

Participants

5

Reactant 4

HCID 312ChlorideHCID 99648032-Amino-5-iodobenzonitrileHCID 109436972-Amino-5-benzylbenzonitrileHCID 178505762HCID 178505762, compound

Product 1

HCID 117463182-Amino-5-(4'-fluorobenzyl)benzonitrile

Sources & evidence

ORD record
ord-7d7bb8393b464a1ba80fb4c204f828fd
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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