Dimethylformamide → 4-(6-Chloro-4-cyclopropyl-2-oxo-3-(2,2,2-trifluoroethyl)-1,2,3,4-tetrahydroquinazolin-4-yl)benzonitrile

HRID 799812Notes

Reaction equation

HRID 799812 reaction equation
[Cl:1][c:2]1[cH:3][c:4]2[c:9]([cH:10][cH:11]1)[NH:8][C:7](=[O:12])[N:6]([CH2:13][C:14]([F:15])([F:16])[F:17])[C:5]2([c:18]1[cH:19][cH:20][c:21]([Br:24])[cH:22][cH:23]1)[CH:25]1[CH2:26][CH2:27]1.[Cu:28][C:29]#[N:30].[O:31]=[CH:32][N:33]([CH3:34])[CH3:35]>>[Cl:1][c:2]1[cH:3][c:4]2[c:9]([cH:10][cH:11]1)[NH:8][C:7](=[O:12])[N:6]([CH2:13][C:14]([F:15])([F:16])[F:17])[C:5]2([c:18]1[cH:19][cH:20][c:21]([C:29]#[N:30])[cH:22][cH:23]1)[CH:25]1[CH2:26][CH2:27]1

Participants

4

Reactant 3

HCID 6228DimethylformamideHCID 118540706-chloro-4-cyclopropyl-4-(4-bromophenyl)-3-(2,2,2-trifluoroethyl)-3,4-dihydroquinazolin-2(1H)-oneHCID 178418546HCID 178418546, compound

Product 1

HCID 118540714-(6-Chloro-4-cyclopropyl-2-oxo-3-(2,2,2-trifluoroethyl)-1,2,3,4-tetrahydroquinazolin-4-yl)benzonitrile

Sources & evidence

ORD record
ord-7ab4dafd5cb845248ee5c3a59ad37a40
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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