Trifluoroacetic acid → 1-[5-(4-Fluorophenyl)-2-methyl-thiazol-4-yl]1-{2-[4-(4-fluorophenyl)-oxazol-2-ylmethyl]-piperazin-1-yl}-methanone

HRID 799883Notes

Reaction equation

HRID 799883 reaction equation
[C:1]([O:2][C:3](=[O:4])[N:8]1[CH2:9][CH:10]([CH2:29][c:30]2[o:31][cH:32][c:33](-[c:35]3[cH:36][cH:37][c:38]([F:41])[cH:39][cH:40]3)[n:34]2)[N:11]([C:14](=[O:15])[c:16]2[n:17][c:18]([CH3:28])[s:19][c:20]2-[c:21]2[cH:22][cH:23][c:24]([F:27])[cH:25][cH:26]2)[CH2:12][CH2:13]1)([CH3:5])([CH3:6])[CH3:7].[OH:42][C:43]([C:44]([F:45])([F:46])[F:47])=[O:48]>>[NH:8]1[CH2:9][CH:10]([CH2:29][c:30]2[o:31][cH:32][c:33](-[c:35]3[cH:36][cH:37][c:38]([F:41])[cH:39][cH:40]3)[n:34]2)[N:11]([C:14](=[O:15])[c:16]2[n:17][c:18]([CH3:28])[s:19][c:20]2-[c:21]2[cH:22][cH:23][c:24]([F:27])[cH:25][cH:26]2)[CH2:12][CH2:13]1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 67157954(RS)-4-{1-[5-(4-Fluorophenyl)-2-methylthiazol-4-yl]-methanoyl}-3-[4-(4-fluoro-phenyl)-oxazol-2-ylmethyl]-piperazine-1-carboxylic acid tert-butyl ester

Product 1

HCID 671579551-[5-(4-Fluorophenyl)-2-methyl-thiazol-4-yl]1-{2-[4-(4-fluorophenyl)-oxazol-2-ylmethyl]-piperazin-1-yl}-methanone

Sources & evidence

ORD record
ord-97531f155a18455fa1475c567a6f8de3
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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