Sodium ion → 2,6-Dichloro-5-fluoronicotinic acid

HRID 799917Notes

Reaction equation

HRID 799917 reaction equation
[Cl:12][c:13]1[c:14]([C:15]#[N:16])[cH:17][c:18]([F:19])[c:20]([Cl:21])[n:22]1.[Cl:28][P:29]([Cl:30])([Cl:31])([Cl:32])[Cl:33].[Cl:34][c:35]1[c:36]([C:37](=[O:38])[NH2:39])[cH:40][c:41]([F:45])[c:42]([Cl:44])[n:43]1.[N:51]([O-:52])=[O:53].[Na+:54].[OH:1][c:2]1[c:3]([C:4]#[N:5])[cH:6][c:7]([F:8])[c:9]([OH:10])[n:11]1.[P:23]([Cl:24])([Cl:25])([Cl:26])=[O:27].[S:46](=[O:47])(=[O:48])([OH:49])[OH:50]>>[OH:1][C:37]([c:36]1[c:35]([Cl:34])[n:43][c:42]([Cl:44])[c:41]([F:45])[cH:40]1)=[O:38]

Participants

9

Reactant 8

HCID 923Sodium ionHCID 946NitriteHCID 1118Sulfuric AcidHCID 24813Phosphorus oxychlorideHCID 24819Phosphorus pentachlorideHCID 27338492,6-Dichloro-5-fluoro-3-pyridinecarbonitrileHCID 27740222,6-Dichloro-5-fluoronicotinamideHCID 178510174HCID 178510174, compound

Product 1

HCID 27336592,6-Dichloro-5-fluoronicotinic acid

Sources & evidence

ORD record
ord-86b618ebde684fe0923e27b7795d9739
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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