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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 800088Generated: October 30, 2026

Dimethylformamide → 6-Fluoro-1'-(4-methoxybenzyl)-2'-oxo-1',2'-dihydrospiro[1-benzofuran-3,3'-indole]-5-carbonitrile

https://huagongshe.com/reaction/800088

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDimethylformamideHCID 6228—
ReactantTetrahydrofuranHCID 8028—
ReactantChloroiodomethaneHCID 11644—
ReactantCarbonate IonHCID 19660—
ReactantCesium cationHCID 104967—
Reactant2-fluoro-4-hydroxy-5-[1-(4-methoxybenzyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]benzonitrileHCID 67358996—
Product6-Fluoro-1'-(4-methoxybenzyl)-2'-oxo-1',2'-dihydrospiro[1-benzofuran-3,3'-indole]-5-carbonitrileHCID 59352534—

Provenance & Evidence

DOI10.1039/C8SC04228D
Source datasetTest data from https://doi.org/10.1039/C8SC04228D
ORD IDord-2fc1debdd6eb40f4a3a36c561afb329d
Source noteTest data from https://doi.org/10.1039/C8SC04228D