Dimethylformamide → 6-Fluoro-1'-(4-methoxybenzyl)-2'-oxo-1',2'-dihydrospiro[1-benzofuran-3,3'-indole]-5-carbonitrile

HRID 800088Notes

Reaction equation

HRID 800088 reaction equation
[C:33](=[O:34])([O-:35])[O-:36].[CH3:44][N:45]([CH3:46])[CH:47]=[O:48].[Cl:30][CH2:31][I:32].[Cs+:37].[Cs+:38].[F:1][c:2]1[c:3]([C:4]#[N:5])[cH:6][c:7]([CH:11]2[C:12](=[O:29])[N:13]([CH2:20][c:21]3[cH:22][cH:23][c:24]([O:27][CH3:28])[cH:25][cH:26]3)[c:14]3[cH:15][cH:16][cH:17][cH:18][c:19]32)[c:8]([OH:10])[cH:9]1.[O:39]1[CH2:40][CH2:41][CH2:42][CH2:43]1>>[F:1][c:2]1[c:3]([C:4]#[N:5])[cH:6][c:7]2[c:8]([cH:9]1)[O:10][CH2:31][C:11]21[C:12](=[O:29])[N:13]([CH2:20][c:21]2[cH:22][cH:23][c:24]([O:27][CH3:28])[cH:25][cH:26]2)[c:14]2[cH:15][cH:16][cH:17][cH:18][c:19]21

Participants

7

Reactant 6

HCID 6228DimethylformamideHCID 8028TetrahydrofuranHCID 11644ChloroiodomethaneHCID 19660Carbonate IonHCID 104967Cesium cation2×HCID 673589962-fluoro-4-hydroxy-5-[1-(4-methoxybenzyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]benzonitrile

Product 1

HCID 593525346-Fluoro-1'-(4-methoxybenzyl)-2'-oxo-1',2'-dihydrospiro[1-benzofuran-3,3'-indole]-5-carbonitrile

Sources & evidence

ORD record
ord-2fc1debdd6eb40f4a3a36c561afb329d
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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