Chloroacetyl chloride → HCID 178463656, compound

HRID 80016Notes

Reaction equation

HRID 80016 reaction equation
[CH3:1][C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][C:7]=1[NH2:8].Cl[CH2:10][C:11](Cl)=[O:12].[CH2:14]([N:16]=[C:17]=[S:18])[CH3:15]>>[CH2:14](/[N:16]=[C:17]1\[S:18][CH2:10][C:11](=[O:12])[N:8]\1[C:7]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH3:1])[CH3:15]

Participants

4

Reactant 3

HCID 6577Chloroacetyl chlorideHCID 7242O-ToluidineHCID 10966Ethyl isothiocyanate

Product 1

HCID 178463656HCID 178463656, compound

Procedure

2-[(Z)-Ethylimino]-3-(2-methylphenyl)-thiazolidin-4-one is prepared following Method B and starting from o-tolylamine, chloroacetyl chloride and ethylisothiocyanate. LC-MS: tR=0.59 min, [M+1]+=235, 1H NMR (CDCl3): δ 7.36-7.28 (m, 3H), 7.15-7.10 (m, 1H), 4.01 (s, 2H), 3.41-3.30 (m, 2H), 2.19 (s, 3H), 1.20-1.13 (m, 3H).

Sources & evidence

ORD record
ord-a7da7dce8e724ea68d2843e50aca0c8e
Source dataset
uspto-grants-2014_09
Patent number
USRE045174E1

Reaction notes

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