Sodium ion → 4-[2-(2,2-Dimethyl-5-oxopyrrolidin-1-yl)-1,3-thiazol-4-yl]benzonitrile

HRID 800250Notes

Reaction equation

HRID 800250 reaction equation
[C:1](#[N:2])[c:3]1[cH:4][cH:5][c:6](-[c:9]2[n:10][c:11]([NH:14][C:15]([CH2:16][CH2:17][C:18](=[O:19])[O:20][CH3:21])([CH3:22])[CH3:23])[s:12][cH:13]2)[cH:7][cH:8]1.[CH3:24][Si:25]([N-:26][Si:27]([CH3:28])([CH3:29])[CH3:30])([CH3:31])[CH3:32].[Na+:33].[O:34]1[CH2:35][CH2:36][CH2:37][CH2:38]1>>[C:1](#[N:2])[c:3]1[cH:4][cH:5][c:6](-[c:9]2[n:10][c:11]([N:14]3[C:15]([CH3:22])([CH3:23])[CH2:16][CH2:17][C:18]3=[O:19])[s:12][cH:13]2)[cH:7][cH:8]1

Participants

5

Reactant 4

HCID 923Sodium ionHCID 8028TetrahydrofuranHCID 3280088Npc316347HCID 86618613Methyl 4-{[4-(4-cyanophenyl)-1,3-thiazol-2-yl]amino}-4-methylpentanoate

Product 1

HCID 689027704-[2-(2,2-Dimethyl-5-oxopyrrolidin-1-yl)-1,3-thiazol-4-yl]benzonitrile

Sources & evidence

ORD record
ord-e584369f7fc645c491d0634de9ccd041
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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