Potassium Cation → tert-butyl 4-(3-amino-5-(trifluoromethyl)phenyl)-5,6-dihydropyridine-1(2H)-carboxylate

HRID 800253Notes

Reaction equation

HRID 800253 reaction equation
[Br:1][c:2]1[cH:3][c:4]([NH2:12])[cH:5][c:6]([C:8]([F:9])([F:10])[F:11])[cH:7]1.[C:35](=[O:36])([O-:37])[O-:38].[CH3:13][C:14]1([CH3:15])[C:16]([CH3:17])([CH3:18])[O:19][B:20]([C:21]2=[CH:22][CH2:23][N:24]([C:27](=[O:28])[O:29][C:30]([CH3:31])([CH3:32])[CH3:33])[CH2:25][CH2:26]2)[O:34]1.[K+:39].[K+:40].[O:41]=[CH:42][N:43]([CH3:44])[CH3:45]>>[c:2]1([C:21]2=[CH:22][CH2:23][N:24]([C:27](=[O:28])[O:29][C:30]([CH3:31])([CH3:32])[CH3:33])[CH2:25][CH2:26]2)[cH:3][c:4]([NH2:12])[cH:5][c:6]([C:8]([F:9])([F:10])[F:11])[cH:7]1

Participants

6

Reactant 5

HCID 813Potassium Cation2×HCID 6228DimethylformamideHCID 19660Carbonate IonHCID 27358803-Bromo-5-(trifluoromethyl)anilineHCID 4642098Tert-butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,6-tetrahydropyridine-1-carboxylate

Product 1

HCID 67520234tert-butyl 4-(3-amino-5-(trifluoromethyl)phenyl)-5,6-dihydropyridine-1(2H)-carboxylate

Sources & evidence

ORD record
ord-54fed688e8e74d1ab112d26b82eea844
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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