Hydroxide → 2-Bromo-3',5'-bis(trifluoromethyl)biphenyl-4-carboxylic acid

HRID 800341Notes

Reaction equation

HRID 800341 reaction equation
[Br:4][c:5]1[c:6](-[c:15]2[cH:16][c:17]([C:25]([F:26])([F:27])[F:28])[cH:18][c:19]([C:21]([F:22])([F:23])[F:24])[cH:20]2)[cH:7][cH:8][c:9]([C:11](=[O:12])[O:13][CH3:14])[cH:10]1.[Li+:3].[O:30]1[CH2:31][CH2:32][O:33][CH2:34][CH2:35]1.[OH-:2].[OH2:1].[OH2:29]>>[Br:4][c:5]1[c:6](-[c:15]2[cH:16][c:17]([C:25]([F:26])([F:27])[F:28])[cH:18][c:19]([C:21]([F:22])([F:23])[F:24])[cH:20]2)[cH:7][cH:8][c:9]([C:11](=[O:12])[OH:13])[cH:10]1

Participants

6

Reactant 5

HCID 961HydroxideHCID 962Water2×HCID 28486Lithium ionHCID 312751,4-DioxaneHCID 87381579Methyl 4-[3,5-bis(trifluoromethyl)phenyl]-3-bromobenzoate

Product 1

HCID 866577562-Bromo-3',5'-bis(trifluoromethyl)biphenyl-4-carboxylic acid

Sources & evidence

ORD record
ord-9bb614bcaed84457bff6518caaa18c29
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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