Dichloromethane → 3,5-Dichloro-N-(3-chloro-5-((isobutylamino)methyl)benzyl)-2-hydroxy-N-isobutylbenzenesulfonamide

HRID 801035Notes

Reaction equation

[CH2:46]([Cl:47])[Cl:48].[Cl:1][c:2]1[cH:3][c:4]([CH2:5][N:6]([C:7](=[O:8])[O:9][C:10]([CH3:11])([CH3:12])[CH3:13])[CH2:14][CH:15]([CH3:16])[CH3:17])[cH:18][c:19]([CH2:21][N:22]([S:23](=[O:24])(=[O:25])[c:26]2[c:27]([OH:34])[c:28]([Cl:33])[cH:29][c:30]([Cl:32])[cH:31]2)[CH2:35][CH:36]([CH3:37])[CH3:38])[cH:20]1.[F:39][C:40]([F:41])([F:42])[C:43]([OH:44])=[O:45]>>[Cl:1][c:2]1[cH:3][c:4]([CH2:5][NH:6][CH2:14][CH:15]([CH3:16])[CH3:17])[cH:18][c:19]([CH2:21][N:22]([S:23](=[O:24])(=[O:25])[c:26]2[c:27]([OH:34])[c:28]([Cl:33])[cH:29][c:30]([Cl:32])[cH:31]2)[CH2:35][CH:36]([CH3:37])[CH3:38])[cH:20]1

Participants

Reactant 3

HCID 6344Dichloromethane

HCID 6422Trifluoroacetic acid

HCID 58531453tert-butyl 3-chloro-5-((3,5-dichloro-2-hydroxy-N-isobutylphenylsulfonamido)methyl)benzyl(isobutyl)carbamate

Product 1

HCID 585315243,5-Dichloro-N-(3-chloro-5-((isobutylamino)methyl)benzyl)-2-hydroxy-N-isobutylbenzenesulfonamide

Sources & evidence

ORD record: ord-8abecaf0dea149ac995a445b5d6a8988
Source dataset: Test data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Reaction notes

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