Dichloromethane → 2-(4-(4-Aminopiperidin-1-yl)quinazolin-2-yl)phenol

HRID 801214Notes

Reaction equation

[Cl:39][CH2:40][Cl:41].[F:32][C:33]([F:34])([F:35])[C:36]([OH:37])=[O:38].[OH:1][c:2]1[c:3](-[c:8]2[n:9][c:10]3[cH:11][cH:12][cH:13][cH:14][c:15]3[c:16]([N:18]3[CH2:19][CH2:20][CH:21]([NH:24][C:25](=[O:26])[O:27][C:28]([CH3:29])([CH3:30])[CH3:31])[CH2:22][CH2:23]3)[n:17]2)[cH:4][cH:5][cH:6][cH:7]1>>[OH:1][c:2]1[c:3](-[c:8]2[n:9][c:10]3[cH:11][cH:12][cH:13][cH:14][c:15]3[c:16]([N:18]3[CH2:19][CH2:20][CH:21]([NH2:24])[CH2:22][CH2:23]3)[n:17]2)[cH:4][cH:5][cH:6][cH:7]1

Participants

Reactant 3

HCID 6344Dichloromethane

HCID 6422Trifluoroacetic acid

HCID 136121521Tert-butyl 1-(2-(2-hydroxyphenyl)quinazolin-4-yl)piperidin-4-ylcarbamate

Product 1

HCID 1361214062-(4-(4-Aminopiperidin-1-yl)quinazolin-2-yl)phenol

Sources & evidence

ORD record: ord-23f1b7e6b2ab4d858207fa69fcce2d1e
Source dataset: Test data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Reaction notes

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