Dichloromethane → N,N-Di-Boc-5-(bromomethyl)pyrimidin-2-amine

HRID 801219Notes

Reaction equation

HRID 801219 reaction equation
[Br:20][C:21]([Br:22])([Br:23])[Br:24].[C:25]([CH3:26])([CH3:27])([CH3:28])[O:29][C:30](=[O:31])[N:32]([C:33](=[O:34])[O:35][C:36]([CH3:37])([CH3:38])[CH3:39])[c:40]1[n:41][cH:42][c:43]([CH2:46][OH:47])[cH:44][n:45]1.[Cl:48][CH2:49][Cl:50].[c:1]1([P:2]([c:3]2[cH:4][cH:5][cH:6][cH:7][cH:8]2)[c:9]2[cH:10][cH:11][cH:12][cH:13][cH:14]2)[cH:15][cH:16][cH:17][cH:18][cH:19]1>>[CH2:21]([Br:24])[c:43]1[cH:42][n:41][c:40]([N:32]([C:30]([O:29][C:25]([CH3:26])([CH3:27])[CH3:28])=[O:31])[C:33](=[O:34])[O:35][C:36]([CH3:37])([CH3:38])[CH3:39])[n:45][cH:44]1

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 11205Carbon tetrabromideHCID 11776TriphenylphosphineHCID 220360932-[N,N-bis(tert-butoxycarbonyl)amino]-5-hydroxymethyl-pyrimidin

Product 1

HCID 22036062N,N-Di-Boc-5-(bromomethyl)pyrimidin-2-amine

Sources & evidence

ORD record
ord-98eae1e02ec64b8fb9ef147aa0cb67d8
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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