Dichloromethane → Tert-butyl 4-[(3-chlorophenyl)(1-hydroxycyclohexyl)acetyl]piperazine-1-carboxylate

HRID 801479Notes

Reaction equation

HRID 801479 reaction equation
[CH2:39]([Cl:40])[Cl:41].[CH3:32][CH2:33][N:34]([CH2:35][CH3:36])[CH2:37][CH3:38].[Cl:1][c:2]1[cH:3][c:4]([CH:8]([C:9](=[O:10])[OH:11])[C:12]2([OH:18])[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17]2)[cH:5][cH:6][cH:7]1.[N:19]1([C:25](=[O:26])[O:27][C:28]([CH3:29])([CH3:30])[CH3:31])[CH2:20][CH2:21][NH:22][CH2:23][CH2:24]1>>[Cl:1][c:2]1[cH:3][c:4]([CH:8]([C:9](=[O:11])[N:22]2[CH2:21][CH2:20][N:19]([C:25](=[O:26])[O:27][C:28]([CH3:29])([CH3:30])[CH3:31])[CH2:24][CH2:23]2)[C:12]2([OH:18])[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17]2)[cH:5][cH:6][cH:7]1

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 8471TriethylamineHCID 143452tert-Butyl piperazine-1-carboxylateHCID 68853928(3-Chlorophenyl)(1-hydroxycyclohexyl)acetic acid

Product 1

HCID 68856003Tert-butyl 4-[(3-chlorophenyl)(1-hydroxycyclohexyl)acetyl]piperazine-1-carboxylate

Sources & evidence

ORD record
ord-5ee97ff8f231449cb82e19f869a54990
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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