反应详情

温度

200 °C

Hydrazine hydrate (5 mL) was added to solution of 2-fluoro-4-[3-(4-methyl-pyridin-3-yl)-2-oxo-imidazolidin-1-yl]-benzaldehyde O-methyl-oxime (I-121b: 350 mg, 0.917 mmol) in 2-methoxy methanol (10 mL). The resulting mixture was heated to 200° C. and maintained for 2 days. The reaction was monitored by TLC (5% MeOH in CHCl3). The reaction mixture was cooled to room temperature and concentrated. The crude product was purified by column chromatography on silica gel (4% MeOH in CHCl3), washed with ether and dried to afford 105 mg of the product (39.17% yield).

1. temperaturemaintained for 2 days
2. temperatureThe reaction mixture was cooled to room temperature
3. concentrationconcentrated
4. customThe crude product was purified by column chromatography on silica gel (4% MeOH in CHCl3)
5. washwashed with ether
6. customdried