1-Butanol → 1-Boc-4-(6-methyl-5-nitro-2-pyridinyl)-piperazine

HRID 801553Notes

Reaction equation

HRID 801553 reaction equation
[CH2:33]([OH:34])[CH2:35][CH2:36][CH3:37].[CH3:25][CH2:26][N:27]([CH2:28][CH3:29])[CH2:30][CH3:31].[Cl:1][c:2]1[cH:3][cH:4][c:5]([N+:9](=[O:10])[O-:11])[c:6]([CH3:8])[n:7]1.[N:12]1([C:18](=[O:19])[O:20][C:21]([CH3:22])([CH3:23])[CH3:24])[CH2:13][CH2:14][NH:15][CH2:16][CH2:17]1.[OH2:32]>>[c:2]1([N:15]2[CH2:14][CH2:13][N:12]([C:18](=[O:19])[O:20][C:21]([CH3:22])([CH3:23])[CH3:24])[CH2:17][CH2:16]2)[cH:3][cH:4][c:5]([N+:9](=[O:10])[O-:11])[c:6]([CH3:8])[n:7]1

Participants

6

Reactant 5

HCID 2631-ButanolHCID 962WaterHCID 8471TriethylamineHCID 143452tert-Butyl piperazine-1-carboxylateHCID 2531236-Chloro-2-methyl-3-nitropyridine

Product 1

HCID 685380371-Boc-4-(6-methyl-5-nitro-2-pyridinyl)-piperazine

Sources & evidence

ORD record
ord-c22f32e180b34aaca1fab25265cc176a
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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