Potassium Cation → 2-Bromo-7-hydroxymethylimidazo[5,1-b]thiazole

HRID 801758Notes

Reaction equation

HRID 801758 reaction equation
[Br:1][c:2]1[cH:3][n:4]2[c:5]([s:6]1)[c:7]([C:10](=[O:11])[O:12][CH2:13][CH3:14])[n:8][cH:9]2.[C:31]([CH:32]([CH:33]([C:34]([O-:35])=[O:36])[OH:37])[OH:38])([O-:39])=[O:40].[CH3:15][c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1.[CH3:22][CH:23]([CH2:24][AlH:25][CH2:26][CH:27]([CH3:28])[CH3:29])[CH3:30].[Cl:43][CH2:44][Cl:45].[K+:42].[Na+:41]>>[Br:1][c:2]1[cH:3][n:4]2[c:5]([s:6]1)[c:7]([CH2:10][OH:11])[n:8][cH:9]2

Participants

8

Reactant 7

HCID 813Potassium CationHCID 923Sodium ionHCID 1140TolueneHCID 6344DichloromethaneHCID 14487Diisobutylaluminum hydrideHCID 38061142,3-DihydroxybutanedioateHCID 59168405Ethyl 2-bromoimidazo[5,1-b]thiazole-7-carboxylate

Product 1

HCID 591684062-Bromo-7-hydroxymethylimidazo[5,1-b]thiazole

Sources & evidence

ORD record
ord-76303ff7a0d84679bc67afa4acef8c40
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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