Dichloromethane → 6-Chloro-1-(3-methoxypropyl)-2-piperidin-3-ylbenzimidazole

HRID 801887Notes

Reaction equation

HRID 801887 reaction equation
[Cl:1][c:2]1[cH:3][cH:4][c:5]2[c:6]([n:7]([CH2:23][CH2:24][CH2:25][O:26][CH3:27])[c:8]([CH:10]3[CH2:11][N:12]([C:16]([O:17][C:18]([CH3:19])([CH3:20])[CH3:21])=[O:22])[CH2:13][CH2:14][CH2:15]3)[n:9]2)[cH:28]1.[Cl:36][CH2:37][Cl:38].[OH:29][C:30]([C:31]([F:32])([F:33])[F:34])=[O:35]>>[Cl:1][c:2]1[cH:3][cH:4][c:5]2[c:6]([n:7]([CH2:23][CH2:24][CH2:25][O:26][CH3:27])[c:8]([CH:10]3[CH2:11][NH:12][CH2:13][CH2:14][CH2:15]3)[n:9]2)[cH:28]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 66786178Tert-butyl 3-[6-chloro-1-(3-methoxypropyl)benzimidazol-2-yl]piperidine-1-carboxylate

Product 1

HCID 667856446-Chloro-1-(3-methoxypropyl)-2-piperidin-3-ylbenzimidazole

Sources & evidence

ORD record
ord-cd833aca2dc54d61adf87ad84c9d5622
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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