Diethyl Ether → N-(4-(3-(2-amino-5-fluoropyrimidin-4-yl)pyridin-2-yloxy)phenyl)4-phenylphthalazin-1-amine

HRID 801903Notes

Reaction equation

HRID 801903 reaction equation
[CH3:56][CH2:57][O:58][CH2:59][CH3:60].[Cl:46][CH2:47][Cl:48].[F:1][c:2]1[c:3](-[c:16]2[c:17]([O:22][c:23]3[cH:24][cH:25][c:26]([NH:29][c:30]4[n:31][n:32][c:33](-[c:40]5[cH:41][cH:42][cH:43][cH:44][cH:45]5)[c:34]5[cH:35][cH:36][cH:37][cH:38][c:39]45)[cH:27][cH:28]3)[n:18][cH:19][cH:20][cH:21]2)[n:4][c:5]([NH:8][C:9](=[O:10])[O:11][C:12]([CH3:13])([CH3:14])[CH3:15])[n:6][cH:7]1.[F:49][C:50]([F:51])([F:52])[C:53]([OH:54])=[O:55]>>[F:1][c:2]1[c:3](-[c:16]2[c:17]([O:22][c:23]3[cH:24][cH:25][c:26]([NH:29][c:30]4[n:31][n:32][c:33](-[c:40]5[cH:41][cH:42][cH:43][cH:44][cH:45]5)[c:34]5[cH:35][cH:36][cH:37][cH:38][c:39]45)[cH:27][cH:28]3)[n:18][cH:19][cH:20][cH:21]2)[n:4][c:5]([NH2:8])[n:6][cH:7]1

Participants

5

Reactant 4

HCID 3283Diethyl EtherHCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 66731483tert-Butyl 5-fluoro-4-(2-(4-(4-phenylphthalazin-1-ylamino)phenoxy)pyridin-3-yl)pyrimidin-2-ylcarbamate

Product 1

HCID 24856045N-(4-(3-(2-amino-5-fluoropyrimidin-4-yl)pyridin-2-yloxy)phenyl)4-phenylphthalazin-1-amine

Sources & evidence

ORD record
ord-712c0a3b182547718e04e8c5360e00aa
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

Loading…