Hydrochloric Acid → HCID 68784416, compound

HRID 80197Notes

Reaction equation

HRID 80197 reaction equation
[ClH:1].[S:2]1[C:6]2[CH:7]=[C:8]([N:11]3[CH2:15][CH2:14][N:13]([C:16]4[CH:17]=[N:18][CH:19]=[CH:20][C:21]=4[NH:22]C(=O)C)[C:12]3=[O:26])[CH:9]=[CH:10][C:5]=2[N:4]=[CH:3]1.CO>C(O)C.C(Cl)(Cl)Cl>[ClH:1].[NH2:22][C:21]1[CH:20]=[CH:19][N:18]=[CH:17][C:16]=1[N:13]1[CH2:14][CH2:15][N:11]([C:8]2[CH:9]=[CH:10][C:5]3[N:4]=[CH:3][S:2][C:6]=3[CH:7]=2)[C:12]1=[O:26]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 59636268N-[3-(3-Benzothiazol-6-yl-2-oxo-imidazolidin-1-yl)-pyridin-4-yl]-acetamide

Product 1

HCID 68784416HCID 68784416, compoundYield 29.02%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 6212ChloroformSolvent

Conditions

Temperature
65 °C

Procedure

6N HCl (3 mL) was added to a solution of N-[3-(3-benzothiazol-6-yl-2-oxo-imidazolidin-1-yl)-pyridin-4-yl]-acetamide (150A: 70 mg, 0.198 mmol) in ethanol (3 mL) and the resulting mixture was refluxed at 65° C. overnight. The reaction was monitored by TLC (10% MeOH in CHCl3). The reaction mixture was concentrated and the concentrate was washed with diethyl ether and dried to afford 20 mg of the product (29.02% yield).

Workup

  1. concentrationThe reaction mixture was concentrated
  2. washthe concentrate was washed with diethyl ether
  3. customdried

Sources & evidence

ORD record
ord-3273931820824dc48946726edd6b5800
Source dataset
uspto-grants-2014_09
Patent number
USRE045173E1

Reaction notes

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