Tetrahydrofuran → 4-{4-[4-(3,4-Difluoro-phenyl)-2-oxo-oxazolidine-3-carbonyl]-piperazin-1-yl}-1-phenyl-cyclohexanecarbonitrile

HRID 802150Notes

Reaction equation

HRID 802150 reaction equation
[CH2:47]1[O:48][CH2:49][CH2:50][CH2:51]1.[N+:1]([c:2]1[cH:3][cH:4][c:5]([O:6][C:11](=[O:12])[N:13]2[C:14](=[O:26])[O:15][CH2:16][CH:17]2[c:18]2[cH:19][c:20]([F:25])[c:21]([F:24])[cH:22][cH:23]2)[cH:7][cH:8]1)([O-:9])=[O:10].[c:27]1([C:33]2([C:45]#[N:46])[CH2:34][CH2:35][CH:36]([N:39]3[CH2:40][CH2:41][NH:42][CH2:43][CH2:44]3)[CH2:37][CH2:38]2)[cH:28][cH:29][cH:30][cH:31][cH:32]1>>[C:11](=[O:12])([N:13]1[C:14](=[O:26])[O:15][CH2:16][CH:17]1[c:18]1[cH:19][c:20]([F:25])[c:21]([F:24])[cH:22][cH:23]1)[N:42]1[CH2:41][CH2:40][N:39]([CH:36]2[CH2:35][CH2:34][C:33]([c:27]3[cH:28][cH:29][cH:30][cH:31][cH:32]3)([C:45]#[N:46])[CH2:38][CH2:37]2)[CH2:44][CH2:43]1

Participants

4

Reactant 3

HCID 8028TetrahydrofuranHCID 220490874-(3,4-Difluorophenyl)-3-(4-nitrophenyloxy-carbonyl)-2-oxo-oxazolidineHCID 229934561-Phenyl-4-piperazin-1-yl-cyclohexanecarbonitrile

Product 1

HCID 104358404-{4-[4-(3,4-Difluoro-phenyl)-2-oxo-oxazolidine-3-carbonyl]-piperazin-1-yl}-1-phenyl-cyclohexanecarbonitrile

Sources & evidence

ORD record
ord-71b66a4f90304222a37c5871e4aeb1fa
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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